Components Of Most Influential Components - 992 Words

We identified the affected components of most influential components in both type of perturbations. We combined all the four environmental conditions to construct the network of the most influential components with downstream targets. On these networks we mapped druggable proteins and cancer associated genes. Under inactivating perturbations, we obtained the network of PI3K, EGFR, PP2A, GRK and CaM (Figure 7A). Under activating perturbations, we obtained the network of influential components i.e. EGFR, IL1_TNFR, ERK, SHP2, RKIP, Ras, Gbg_i, Fak, Integrins, and PP2A (Figure 7B). The ranking of these components based on number of affected components is shown in Table 4. We observed that the EGFR is affecting most number of components under activating as well as inactivating perturbations. Interestingly, EGFR is a validated drug target for cancer [34]. The other influential components such as PI3K, ERK, and Ras have been previously explored in multiple cancer types. However, the influential components consist of the most important drug candidates that block cell proliferation in cancer cells. Some of these components have been associated with the drug resistance. For example, in non-small cell lung cancer, EGFR showed mutation in its kinase domain, Epithelial–mesenchymal transition, and mechanisms to develop resistance to gefitinib [35]. In colorectal, and head and neck cancers KRAS mutation, EGFR-S492R mutation, and increased ErBb signaling are responsible for resistanceShow MoreRelated Roger’s Theory as compared to that of Ellis’ Theory Essay973 Words   |  4 PagesAnderson (n.d) states, â€Å"Carl Rogers, a pioneering psychotherapist and the most influential psychologist in American history was one of the most prominent people of his time.† Rogers’ ideas and practices brought about a change in the school of humanistic psychology. 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